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Which incumbent US Senator running for re-election in 2022 is likely to lose?
Johnson(R-WI),Cortez Masto(D-NV),Warnock(D-GA), Rubio(R-FL),or Kelly(D-AZ)?
Johnson(R-WI) is most likely to lose re-election. Cortez Masto(D-NV),Kelly(D-AZ), and Warnock(D-GA) survive due to the weakness of the Republican challengers. Rubio(R-FL) seat could go either way.
Regarding the OPEN US Senate seats.
PA(OPEN Toomey-R) is most likely to flip. After that is NC(OPEN Burr-R),and OH(OPEN Portman-R).
VT(OPEN Leahy-D) stays in the Democratic column. AL(OPEN Shelby-R) and MO(OPEN Blunt-R) stays in the Republican column.